Funding

We are grateful for all third party funding as well as for institutional support, and support by the Edinger foundation. 

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Seminars

Edinger Seminar
The Seminars of the Edinger Institute take place in building 89 (Neuroscience tower), seminar room ground floor. Campus of the Goethe University Clinic.

Meetings

Mobirise

Barriers of the CNS
Gordon Research Conference

Visit the official meeting homepage

Due to the Covid-19 pandemic, the GRC has been cancelled for 2020 and has been postponed to 2022!!
For further information please check the official website.

Mobirise

24th INTERNATIONAL
SYMPOSIUM ON SIGNAL TRANSDUCTION
AT THE BLOOD-BRAIN BARRIERS
September 21 – 23, 2022 

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Cerebral Vascular Biology (CVB 2021)
June 18 – 22, 2023 in Uppsala, Sweden.

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Due to the Covid-19 pandemic, the meeting has been cancelled for June 20th-24th 2021!!
For further information please check the new official website.

Publications

Selected original articles

for a complete list see

Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d'Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Sience 375(6582):eabm4459. https://dx.doi.org/10.1126/science.abm4459

Guérit, S., Fidan E., Macas J., Czupalla C.J., Figueiredo R., Vijikumar A., Yalcin B.H., Thom S., Winter P., Gerhardt H., Devraj K., Liebner S. (2020) Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance Progress in Neurobiology, https://doi.org/10.1016/j.pneurobio.2020.101937

Winkler, L., Blasig, R., Breitkreuz-Korff, O., Berndt, P., Dithmer, S., Helms, H., Puchkov, D., Devraj, K., Kaya, M., Qin, Z., Liebner, S., Wolburg, H., Andjelkovic, A., Rex, A., Blasig, I., Haseloff, R. (2020). Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 89(), 271678X20904687. https://dx.doi.org/10.1177/0271678x20904687

Díaz-Coránguez, M., Lin, C., Liebner, S., Antonetti, D. (2020). Norrin restores blood-retinal barrier properties after vascular endothelial growth factor–induced permeability Journal of Biological Chemistry 295(14), 4647-4660. https://dx.doi.org/10.1074/jbc.ra119.011273

Francisco, D., Marchetti, L., Rodríguez-Lorenzo, S., Frías-Anaya, E., Figueiredo, R., Heymanns, M., Culot, M., Santa-Maria, A., Deli, M., Germano, R., Vanhollebeke, B., Kakogiannos, N., Giannotta, M., Dejana, E., Dominguez-Belloso, A., Liebner, S., Schuster, M., Klok, H., Wiatr, M., Schroten, H., Tenenbaum, T., Kooij, G., Winter, P., Romero, I., Vries, H., Engelhardt, B., Bruggmann, R. (2020). Advancing brain barriers RNA sequencing: guidelines from experimental design to publication Fluids and Barriers of the CNS 17(1), 51. https://dx.doi.org/10.1186/s12987-020-00207-2

Benz, F., Wichitnaowarat, V., Lehmann, M., Germano, R., Mihova, D., Macas, J., Adams, R., Taketo, M., Plate, K., Guérit, S., Vanhollebeke, B., Liebner, S. (2019). Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice. eLife 8(), 204. https://dx.doi.org/10.7554/elife.43818

Demolli, S., Doddaballapur, A., Devraj, K., Stark, K., Manavski, Y., Eckart, A., Zehendner, C., Lucas, T., Korff, T., Hecker, M., Massberg, S., Liebner, S., Kaluza, D., Boon, R., Dimmeler, S. (2017). Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovascular research 113(6), 681 - 691. https://dx.doi.org/10.1093/cvr/cvx032

Bauer, S., Alphen, N., Becker, A., Chiocchetti, A., Deichmann, R., Deller, T., Freiman, T., Freitag, C., Gehrig, J., Hermsen, A., Jedlicka, P., Kell, C., Klein, K., Knake, S., Kullmann, D., Liebner, S., Norwood, B., Omigie, D., Plate, K., Reif, A., Reif, P., Reiss, Y., Roeper, J., Ronellenfitsch, M., Schorge, S., Schratt, G., Schwarzacher, S., Steinbach, J., Strzelczyk, A., Triesch, J., Wagner, M., Walker, M., Wegner, F., Rosenow, F. (2017). Personalized translational epilepsy research — Novel approaches and future perspectives: Part II: Experimental and translational approaches Epilepsy & Behavior https://dx.doi.org/10.1016/j.yebeh.2017.06.040

Hu, J., Dziumbla, S., Lin, J., Bibli, S., Zukunft, S., Mos, J., Awwad, K., Frömel, T., Jungmann, A., Devraj, K., Cheng, Z., Wang, L., Fauser, S., Eberhart, C., Sodhi, A., Hammock, B., Liebner, S., Müller, O., Glaubitz, C., Hammes, H., Popp, R., Fleming, I. (2017). Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature 552(7684), 248 - 252. https://dx.doi.org/10.1038/nature25013

Ziegler, N., Awwad, K., Fisslthaler, B., Reis, M., Devraj, K., Corada, M., Minardi, S., Dejana, E., Plate, K., Fleming, I., Liebner, S. (2016). β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. The Journal of neuroscience : the official journal of the Society for Neuroscience 36(34), 8921 - 8935. https://dx.doi.org/10.1523/jneurosci.0148-16.2016

Reis, M., Czupalla, C., Ziegler, N., Devraj, K., Zinke, J., Seidel, S., Heck, R., Thom, S., Macas, J., Bockamp, E., Fruttiger, M., Taketo, M., Dimmeler, S., Plate, K., Liebner, S. (2012). Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression. Journal of Experimental Medicine 209(9), 1611 - 1627. https://dx.doi.org/10.1084/jem.20111580

Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., Taketo, M., Melchner, H., Plate, K., Gerhardt, H., Dejana, E. (2008). Wnt/beta-catenin signaling controls development of the blood-brain barrier. The Journal of cell biology 183(3), 409 - 417. https://dx.doi.org/10.1083/jcb.200806024

Address

Institute of Neurology (Edinger-Institute)
University Hospital, Goethe University Frankfurt
Heinrich-Hoffmann-Str. 7
Building 89, 4.Floor, R402
60528 Frankfurt/Main, Germany

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