Endothelial cells (ECs) lining the lumen of blood vessels are primarily important for the delivery of oxygen and nutrients, as well as for the detoxification of body tissues. In vertebrates, the development of the vascular system takes place as vasculo- (de novo formation of vessels) and angiogenesis (growth from pre-existing vessels) and is regulated by growth factors like VEGF, PDGF-BB, Ang-1/-2, TGFβ and Wnts. Depending on their localization in specific tissues of the body, blood vessels have to meet their specific physiological needs. The most prominent example of a tissue specific vascular differentiation is the blood-brain barrier (BBB) and blood-retina barrier (BRB), which on the one hand protects the brain from noxious, blood-born substances and on the other hand guarantees the transport of nutrients and debris to and from the brain, respectively. Our group is mainly interested in the molecular mechanisms, which regulate the endothelial differentiation into the barrier phenotype of the BBB. The aim is to understand BBB-formation in order to be able to manipulate endothelial barrier-characteristics under pathological conditions in the brain, such as stroke, tumors and Alzheimer’s disease.
Stefan Liebner, Dr. rer. Nat.
November 27th 1969
Institute of Neurology (Edinger Institute)
University Hospital Frankfurt am Main, Goethe University
60528 Frankfurt/Main, Germany
2005-present Research Group Leader at the Institute of Neurology (Edinger Institute), Medical School, Johann Wolfgang Goethe-University Frankfurt/Main (Director: Prof. Dr. Karl Heinz Plate)
2001-2004 Post-Doc Position at the Instituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) Oncologia Molecolare (IFOM), Milano, Italia (Prof. Dr. Elisabetta Dejana)
1995-2000 PhD- Student at the Eberhard-Karls University Tübingen, Institute for Pathology, Tübingen, Germany PhD Thesis summa cum laude (Supervisor: Prof. Dr. H. Wolburg)
1997-1997 Visiting researcher at the University of Kyoto, Faculty of Medicine, Department of Cell Biology, Kyoto, Japan; Scientific training (Prof. Dr. Shiohiro Tsukita)
1996-1996 Visiting researcher at the Max-Planck-Institut for Physiological und Clinical Research, Bad Nauheim, Germany; Scientific training (PD Dr. Britta Engelhardt; Prof. Dr. Werner Risau)
1995-1995 Institute for Pathology, Eberhard-Karls University Tübingen Diplomathesis (Supervisor: Prof. Dr. H. Wolburg) Eberhard-Karls 1993-1995 University Tübingen Study of Biology; Subject: Animal-Physiology / Zoology / Biochemistry
1993 Technical University Darmstadt, Darmstadt Study of Biology; Subject: Zoology
1990-1992 Technical University Darmstadt, Darmstadt; Study of Biology; Pre-Diploma